Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expression pathway analysis was used to compare the functio...

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Detalles Bibliográficos
Autores principales: Cherif, Hosni, Bisson, Daniel G, Mannarino, Matthew, Rabau, Oded, Ouellet, Jean A, Haglund, Lisbet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442487/
https://www.ncbi.nlm.nih.gov/pubmed/32821059
http://dx.doi.org/10.7554/eLife.54693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442487/
https://www.ncbi.nlm.nih.gov/pubmed/32821059
http://dx.doi.org/10.7554/eLife.54693

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