Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter

Mitochondrial Ca(2+) uptake is mediated by an inner mitochondrial membrane protein called the mitochondrial calcium uniporter. In humans, the uniporter functions as a holocomplex consisting of MCU, EMRE, MICU1 and MICU2, among which MCU and EMRE form a subcomplex and function as the conductive chann...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Han, Yan, She, Ji, Nguyen, Nam X, Mootha, Vamsi K, Bai, Xiao-chen, Jiang, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442490/
https://www.ncbi.nlm.nih.gov/pubmed/32762847
http://dx.doi.org/10.7554/eLife.60513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442490/
https://www.ncbi.nlm.nih.gov/pubmed/32762847
http://dx.doi.org/10.7554/eLife.60513

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