A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene...

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Detalles Bibliográficos
Autores principales: Agarwal, Devika, Sandor, Cynthia, Volpato, Viola, Caffrey, Tara M., Monzón-Sandoval, Jimena, Bowden, Rory, Alegre-Abarrategui, Javier, Wade-Martins, Richard, Webber, Caleb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442652/
https://www.ncbi.nlm.nih.gov/pubmed/32826893
http://dx.doi.org/10.1038/s41467-020-17876-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442652/
https://www.ncbi.nlm.nih.gov/pubmed/32826893
http://dx.doi.org/10.1038/s41467-020-17876-0

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