Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylat...

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Detalles Bibliográficos
Autores principales: Wiese, Maria, Hamdan, Feda H., Kubiak, Klaudia, Diederichs, Christopher, Gielen, Gerrit H., Nussbaumer, Gunther, Carcaboso, Angel M., Hulleman, Esther, Johnsen, Steven A., Kramm, Christof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442654/
https://www.ncbi.nlm.nih.gov/pubmed/32826850
http://dx.doi.org/10.1038/s41419-020-02800-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442654/
https://www.ncbi.nlm.nih.gov/pubmed/32826850
http://dx.doi.org/10.1038/s41419-020-02800-7

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