Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix

Aberrant activation of the hedgehog (Hh) signaling pathway is associated with the formation of medulloblastoma (MB), the most common malignant pediatric brain tumor. However, tumor cells from human and mouse MB can not be passaged or preserved after being adherently cultured. Moreover, Hh signaling...

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Detalles Bibliográficos
Autores principales: Cheng, Yan, Franco-Barraza, Janusz, Wang, Yuan, Zheng, Chaonan, Zhang, Li, Qu, Yanghui, Long, Yaqiu, Cukierman, Edna, Yang, Zeng-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442735/
https://www.ncbi.nlm.nih.gov/pubmed/32457352
http://dx.doi.org/10.1038/s41374-020-0443-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442735/
https://www.ncbi.nlm.nih.gov/pubmed/32457352
http://dx.doi.org/10.1038/s41374-020-0443-2

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