Cargando…
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined. Here we show that persistent antigenic stimulation impaired ADP-coupled oxidative p...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442749/ https://www.ncbi.nlm.nih.gov/pubmed/32661364 http://dx.doi.org/10.1038/s41590-020-0725-2 |