Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined. Here we show that persistent antigenic stimulation impaired ADP-coupled oxidative p...

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Detalles Bibliográficos
Autores principales: Vardhana, Santosha A., Hwee, Madeline A., Berisa, Mirela, Wells, Daniel K., Yost, Kathryn E., King, Bryan, Smith, Melody, Herrera, Pamela S., Chang, Howard Y., Satpathy, Ansuman T., van den Brink, Marcel R.M., Cross, Justin R., Thompson, Craig B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442749/
https://www.ncbi.nlm.nih.gov/pubmed/32661364
http://dx.doi.org/10.1038/s41590-020-0725-2

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