Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Manufacturing of biopharmaceuticals involves recombinant protein expression in host cells followed by extensive purification of the target protein. Yet, host cell proteins (HCPs) may persist in the final drug product, potentially reducing its quality with respect to safety and efficacy. Consequently...

Descripción completa

Detalles Bibliográficos
Autores principales: Esser-Skala, Wolfgang, Segl, Marius, Wohlschlager, Therese, Reisinger, Veronika, Holzmann, Johann, Huber, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442769/
https://www.ncbi.nlm.nih.gov/pubmed/32691086
http://dx.doi.org/10.1007/s00216-020-02796-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442769/
https://www.ncbi.nlm.nih.gov/pubmed/32691086
http://dx.doi.org/10.1007/s00216-020-02796-1

Ejemplares similares