Cargando…

Risuteganib Protects against Hydroquinone–induced Injury in Human RPE Cells

PURPOSE: Cigarette smoking has been implicated in the pathogenesis of AMD. Integrin dysfunctions have been associated with AMD. Herein, we investigate the effect of risuteganib (RSG), an integrin regulator, on RPE cell injury induced by hydroquinone (HQ), an important oxidant in cigarette smoke. MET...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ping, Shao, Zixuan, Besley, Nicholas A., Neal, Samantha E., Buehne, Kristen L., Park, John, Karageozian, Hampar, Karageozian, Vicken, Ryde, Ian T., Meyer, Joel N., Jaffe, Glenn J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443126/ https://www.ncbi.nlm.nih.gov/pubmed/32818234 http://dx.doi.org/10.1167/iovs.61.10.35

Ejemplares similares

The Transcriptome Profile of Retinal Pigment Epithelium and Müller Cell Lines Protected by Risuteganib Against Hydrogen Peroxide Stress
por: Shao, Zixuan, et al.
Publicado: (2022)

Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells
por: Neal, Samantha E., et al.
Publicado: (2020)

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2017)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae
por: Nakanishi, Masataka, et al.
Publicado: (2016)

Medium Depth Influences O(2) Availability and Metabolism in Human RPE Cultures
por: Hass, Daniel T., et al.
Publicado: (2023)

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes
por: Stanton, James B., et al.
Publicado: (2017)

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material
por: Zhang, Qitao, et al.
Publicado: (2019)

Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction
por: Lin, Bin, et al.
Publicado: (2020)

DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency
por: Swinkels, Daniëlle, et al.
Publicado: (2023)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
por: Sreekumar, Parameswaran G., et al.
Publicado: (2016)

Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin
por: Galloway, Chad A., et al.
Publicado: (2018)

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells
por: Vu, Khiem T., et al.
Publicado: (2017)

Light-Induced Smooth Endoplasmic Reticulum Rearrangement in a Unique Interlaced Compartmental Pattern in Macaca mulatta RPE
por: Altera, Annalisa, et al.
Publicado: (2021)

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN
por: Hamuro, Junji, et al.
Publicado: (2023)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease
por: Yiu, Glenn, et al.
Publicado: (2016)

Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function
por: Daniele, Lauren L., et al.
Publicado: (2016)

RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment
por: Wang, Jianfeng, et al.
Publicado: (2016)

Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3
por: Esposito, Nicholas J., et al.
Publicado: (2021)

Crx(Rdy) Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis
por: Occelli, Laurence M., et al.
Publicado: (2016)

Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics
por: Voigt, Andrew P., et al.
Publicado: (2023)

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina
por: Hu, Ping, et al.
Publicado: (2017)

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses
por: Schaefer, Kellie A., et al.
Publicado: (2016)

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2016)

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration
por: Chakraborty, Dibyendu, et al.
Publicado: (2016)

Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration
por: Zhang, Shuqiang, et al.
Publicado: (2016)

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis
por: Arjunan, Pachiappan, et al.
Publicado: (2016)

Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination
por: Simmons, Aaron B., et al.
Publicado: (2016)

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury
por: Woodell, Alex, et al.
Publicado: (2016)

N-Acetylcysteine Amide Protects Against Oxidative Stress–Induced Microparticle Release From Human Retinal Pigment Epithelial Cells
por: Carver, Kyle A., et al.
Publicado: (2016)

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages
por: Collery, Ross F., et al.
Publicado: (2016)

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
por: Pilgrim, Matthew G., et al.
Publicado: (2017)

The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival
por: Lessieur, Emma M., et al.
Publicado: (2017)

Beneficial Effects of Berberine on Oxidized LDL-Induced Cytotoxicity to Human Retinal Müller Cells
por: Fu, Dongxu, et al.
Publicado: (2016)

Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy
por: Mishra, Manish, et al.
Publicado: (2016)

Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4(−/−)Rdh8(−/−) Mice After Light Exposure
por: Parmar, Tanu, et al.
Publicado: (2016)

Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish
por: Sifuentes, Christopher J., et al.
Publicado: (2016)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development
por: Alldredge, Ashley, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_aqpv2h98nqf5udj8kv636m80n6