Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation

The human myelogenous leukemic cell line, K562 undergoes erythroid differentiation by exposure to hemin. Here, we uncovered NSD2 as an innate erythroid differentiation-related factor through a genome-wide CRISPR library screen and explored the regulatory role of NSD2 during myeloid leukemia cell dif...

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Detalles Bibliográficos
Autores principales: Park, Jin Woo, Kang, Joo-Young, Hahm, Ja Young, Kim, Hyun Jeong, Seo, Sang-Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443147/
https://www.ncbi.nlm.nih.gov/pubmed/32826945
http://dx.doi.org/10.1038/s42003-020-01186-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443147/
https://www.ncbi.nlm.nih.gov/pubmed/32826945
http://dx.doi.org/10.1038/s42003-020-01186-8

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