Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes

BACKGROUND AND PURPOSE: mPGES1 catalyses the production of PGE(2), the most abundant prostanoid related to inflammation and pain in arthritis. mPGES1 is suggested to be a safer and more selective drug target in inflammatory conditions compared to the COX enzymes inhibited by NSAIDs. In the present s...

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Detalles Bibliográficos
Autores principales: Tuure, Lauri, Pemmari, Antti, Hämäläinen, Mari, Moilanen, Teemu, Moilanen, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443472/
https://www.ncbi.nlm.nih.gov/pubmed/32449517
http://dx.doi.org/10.1111/bph.15142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443472/
https://www.ncbi.nlm.nih.gov/pubmed/32449517
http://dx.doi.org/10.1111/bph.15142

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