Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects

BACKGROUND: Stroke/thromboembolic events, infections, and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify potential mechanisms underlying adverse even...

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Detalles Bibliográficos
Autores principales: Malekizadeh, Yasaman, Williams, Gareth, Kelson, Mark, Whitfield, David, Mill, Jonathan, Collier, David A., Ballard, Clive, Jeffries, Aaron R., Creese, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443741/
https://www.ncbi.nlm.nih.gov/pubmed/32864416
http://dx.doi.org/10.1002/trc2.12078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443741/
https://www.ncbi.nlm.nih.gov/pubmed/32864416
http://dx.doi.org/10.1002/trc2.12078

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