Long-read individual-molecule sequencing reveals CRISPR-induced genetic heterogeneity in human ESCs

Quantifying the genetic heterogeneity of a cell population is essential to understanding of biological systems. We develop a universal method to label individual DNA molecules for single-base-resolution haplotype-resolved quantitative characterization of diverse types of rare variants, with frequenc...

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Detalles Bibliográficos
Autores principales: Bi, Chongwei, Wang, Lin, Yuan, Baolei, Zhou, Xuan, Li, Yu, Wang, Sheng, Pang, Yuhong, Gao, Xin, Huang, Yanyi, Li, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444080/
https://www.ncbi.nlm.nih.gov/pubmed/32831134
http://dx.doi.org/10.1186/s13059-020-02143-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444080/
https://www.ncbi.nlm.nih.gov/pubmed/32831134
http://dx.doi.org/10.1186/s13059-020-02143-8

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