Initial dose recommendation for sirolimus in paediatric kaposiform haemangioendothelioma patients based on population pharmacokinetics and pharmacogenomics

OBJECTIVE: Sirolimus has been used to treat paediatric kaposiform haemangioendothelioma patients. However, there is considerable pharmacokinetic variability among individuals, and it is difficult to develop an initial dosing regimen. The goal of the present study is to recommend an initial sirolimus...

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Detalles Bibliográficos
Autores principales: Chen, Xiao, Wang, Dong-Dong, Xu, Hong, Li, Zhi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444137/
https://www.ncbi.nlm.nih.gov/pubmed/32815764
http://dx.doi.org/10.1177/0300060520947627