A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported. Both enantiomers of the Michael adducts can be obtained in high enantioselectivity and good yield merely by changing th...

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Detalles Bibliográficos
Autores principales: Hayama, Noboru, Kobayashi, Yusuke, Sekimoto, Eriko, Miyazaki, Anna, Inamoto, Kiyofumi, Kimachi, Tetsutaro, Takemoto, Yoshiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444369/
https://www.ncbi.nlm.nih.gov/pubmed/32874501
http://dx.doi.org/10.1039/d0sc01729a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444369/
https://www.ncbi.nlm.nih.gov/pubmed/32874501
http://dx.doi.org/10.1039/d0sc01729a

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