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High-dose TGF-β1 degrades human nucleus pulposus cells via ALK1-Smad1/5/8 activation

Transforming growth factor β1 (TGF-β1) can promote the proliferation and differentiation of intervertebral disc cells and participates in its repair process. However, whether TGF-β1 engages in the process of disc degeneration has not yet been fully elucidated. The present study aimed to investigate...

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Detalles Bibliográficos
Autores principales: Qu, Zhiqiang, Zhang, Fengxiang, Chen, Weiwei, Lin, Tao, Sun, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444386/
https://www.ncbi.nlm.nih.gov/pubmed/32855718
http://dx.doi.org/10.3892/etm.2020.9088