THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

Apoptosis of cochlear hair cells is a key step towards age-related hearing loss. Although numerous genes have been implicated in the genetic causes of late-onset, progressive hearing loss, few show direct links to the proapoptotic process. By genome-wide linkage analysis and whole exome sequencing,...

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Detalles Bibliográficos
Autores principales: Zhang, Luping, Gao, Yu, Zhang, Ru, Sun, Feifei, Cheng, Cheng, Qian, Fuping, Duan, Xuchu, Wei, Guanyun, Sun, Cheng, Pang, Xiuhong, Chen, Penghui, Chai, Renjie, Yang, Tao, Wu, Hao, Liu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444544/
https://www.ncbi.nlm.nih.gov/pubmed/32776944
http://dx.doi.org/10.1371/journal.pgen.1008953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444544/
https://www.ncbi.nlm.nih.gov/pubmed/32776944
http://dx.doi.org/10.1371/journal.pgen.1008953

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