L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils

Parkinson disease is the most common neurodegenerative movement disorder, estimated to affect one in twenty-five individuals over the age of 80. Mutations in glucocerebrosidase 1 (GBA1) represent the most common genetic risk factor for Parkinson disease. The link between GBA1 mutations and α-synucle...

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Detalles Bibliográficos
Autores principales: Migdalska‐Richards, Anna, Wegrzynowicz, Michal, Harrison, Ian F., Verona, Guglielmo, Bellotti, Vittorio, Spillantini, Maria Grazia, Schapira, Anthony H. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444808/
https://www.ncbi.nlm.nih.gov/pubmed/32833982
http://dx.doi.org/10.1371/journal.pone.0238075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444808/
https://www.ncbi.nlm.nih.gov/pubmed/32833982
http://dx.doi.org/10.1371/journal.pone.0238075

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