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Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes

Protein activity is often regulated by ligand binding or by post-translational modifications such as phosphorylation. Moreover, proteins that are regulated in this way often contain multiple ligand binding sites or modification sites, which can operate to create an ultrasensitive dose response. Here...

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Detalles Bibliográficos
Autores principales: Lagunes, Leonila, Bardwell, Lee, Enciso, German A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444825/
https://www.ncbi.nlm.nih.gov/pubmed/32760072
http://dx.doi.org/10.1371/journal.pcbi.1007966