Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants

"Antibody-breeding" approach potentially generates therapeutic/diagnostic antibody mutants with greater performance than native antibodies. Therein, antibody fragments (e.g., single-chain Fv fragments; scFvs) with a variety of mutations are displayed on bacteriophage to generate diverse ph...

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Detalles Bibliográficos
Autores principales: Kiguchi, Yuki, Oyama, Hiroyuki, Morita, Izumi, Morikawa, Mai, Nakano, Asuka, Fujihara, Wakana, Inoue, Yukari, Sasaki, Megumi, Saijo, Yuki, Kanemoto, Yuki, Murayama, Kaho, Baba, Yuki, Takeuchi, Atsuko, Kobayashi, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445280/
https://www.ncbi.nlm.nih.gov/pubmed/32839506
http://dx.doi.org/10.1038/s41598-020-71037-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445280/
https://www.ncbi.nlm.nih.gov/pubmed/32839506
http://dx.doi.org/10.1038/s41598-020-71037-3

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