T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

In hematopoietic cell transplants, alloreactive T cells mediate the graft-versus-leukemia (GVL) effect. However, leukemia relapse accounts for nearly half of deaths. Understanding GVL failure requires a system in which GVL-inducing T cells can be tracked. We used such a model wherein GVL is exclusiv...

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Detalles Bibliográficos
Autores principales: Zhou, Meng, Sacirbegovic, Faruk, Zhao, Kai, Rosenberger, Sarah, Shlomchik, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445289/
https://www.ncbi.nlm.nih.gov/pubmed/32839441
http://dx.doi.org/10.1038/s41467-020-17991-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445289/
https://www.ncbi.nlm.nih.gov/pubmed/32839441
http://dx.doi.org/10.1038/s41467-020-17991-y

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