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T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
In hematopoietic cell transplants, alloreactive T cells mediate the graft-versus-leukemia (GVL) effect. However, leukemia relapse accounts for nearly half of deaths. Understanding GVL failure requires a system in which GVL-inducing T cells can be tracked. We used such a model wherein GVL is exclusiv...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445289/ https://www.ncbi.nlm.nih.gov/pubmed/32839441 http://dx.doi.org/10.1038/s41467-020-17991-y |