Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain

BACKGROUND: Mutations in the exonuclease domain of POLE, a DNA polymerase associated with DNA replication and repair, lead to cancers with ultra-high mutation rates. Most studies focus on intestinal and uterine cancers with POLE mutations. These cancers exhibit a significant immune cell infiltrate a...

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Detalles Bibliográficos
Autores principales: Huang, Fangjin, Tanaka, Hisashi, Knudsen, Beatrice S., Rutgers, Joanne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446057/
https://www.ncbi.nlm.nih.gov/pubmed/32838755
http://dx.doi.org/10.1186/s12881-020-01089-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446057/
https://www.ncbi.nlm.nih.gov/pubmed/32838755
http://dx.doi.org/10.1186/s12881-020-01089-9

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