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Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination

BACKGROUND: Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized that BM742401 is a tumor suppressor lncRNA epigenetically silenced by promoter...

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Detalles Bibliográficos
Autores principales: Li, Zhenhai, Kumar, Shaji, Jin, Dong-Yan, Calin, George A., Chng, Wee-Joo, Siu, Kam-Leung, Poon, Ming-Wai, Chim, Chor Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446116/
https://www.ncbi.nlm.nih.gov/pubmed/32855620
http://dx.doi.org/10.1186/s12935-020-01504-4