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Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells

BACKGROUND: Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. However, the molecular mechanisms underlying these effects are not fully understood. Recent studies on IGFBP-3 have indicated...

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Detalles Bibliográficos
Autores principales: Igarashi, Ko, Yui, Yoshihiro, Watanabe, Kenta, Kumai, Jun, Nishizawa, Yasuko, Miyaura, Chisato, Inada, Masaki, Sasagawa, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446217/
https://www.ncbi.nlm.nih.gov/pubmed/32831047
http://dx.doi.org/10.1186/s12885-020-07310-5