Genomic Instability and TP53 Genomic Alterations Associate With Poor Antiproliferative Response and Intrinsic Resistance to Aromatase Inhibitor Treatment

PURPOSE: Although aromatase inhibitor (AI) treatment is effective in estrogen receptor–positive postmenopausal breast cancer, resistance is common and incompletely explained. Genomic instability, as measured by somatic copy number alterations (SCNAs), is important in breast cancer development and pr...

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Detalles Bibliográficos
Autores principales: Schuster, Eugene F., Gellert, Pascal, Segal, Corrinne V., López-Knowles, Elena, Buus, Richard, Cheang, Maggie Chon U., Morden, James, Robertson, John, Bliss, Judith M., Smith, Ian, Dowsett, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2019
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446335/
https://www.ncbi.nlm.nih.gov/pubmed/32914010
http://dx.doi.org/10.1200/PO.18.00286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446335/
https://www.ncbi.nlm.nih.gov/pubmed/32914010
http://dx.doi.org/10.1200/PO.18.00286

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