Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

Phosphorylation is a key regulation event in cellular signaling. Sensing the underlying kinase activity is of crucial importance for its fundamental understanding and for drug development. For this, modular kinase activity sensing concepts are urgently needed. We engineered modular serine kinase sen...

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Detalles Bibliográficos
Autores principales: Xu, Xiaolu, Lemmens, Lenne J. M., den Hamer, Anniek, Merkx, Maarten, Ottmann, Christian, Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446724/
https://www.ncbi.nlm.nih.gov/pubmed/32874496
http://dx.doi.org/10.1039/d0sc00074d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446724/
https://www.ncbi.nlm.nih.gov/pubmed/32874496
http://dx.doi.org/10.1039/d0sc00074d

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