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Examining the role of phosphorylation of p19(INK4d) in its stability and ubiquitination using chemical protein synthesis

p19(INK4d) plays an important role in the regulation of the cell cycle by inhibiting the function of cyclin-dependent kinases 4/6 that is responsible for the phosphorylation and deactivation of the retinoblastoma protein (pRb) tumour suppressor. Recently, it was reported that phosphorylation of p19(...

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Detalles Bibliográficos
Autores principales: Msallam, Muna, Sun, Hao, Meledin, Roman, Franz, Pauline, Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446725/
https://www.ncbi.nlm.nih.gov/pubmed/32874495
http://dx.doi.org/10.1039/c9sc06300e