Cargando…
Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile
The intestinal pathogen Clostridioides difficile exhibits heterogeneity in motility and toxin production. This phenotypic heterogeneity is achieved through phase variation by site-specific recombination via the DNA recombinase RecV, which reversibly inverts the “flagellar switch” upstream of the flg...
Autores principales: | Trzilova, Dominika, Anjuwon-Foster, Brandon R., Torres Rivera, Dariana, Tamayo, Rita |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446863/ https://www.ncbi.nlm.nih.gov/pubmed/32785266 http://dx.doi.org/10.1371/journal.ppat.1008708 |
Ejemplares similares
-
Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides difficile infection
por: Trzilova, Dominika, et al.
Publicado: (2022) -
Phase variation of Clostridium difficile virulence factors
por: Anjuwon-Foster, Brandon R., et al.
Publicado: (2017) -
A genetic switch controls the production of flagella and toxins in Clostridium difficile
por: Anjuwon-Foster, Brandon R., et al.
Publicado: (2017) -
RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility
por: Edwards, Adrianne N., et al.
Publicado: (2019) -
Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence
por: Garrett, Elizabeth M., et al.
Publicado: (2019)