An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells

VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell growth, we performed unbiased cell line profiling studies with the selective VPS34 inhibitor PIK-III and identified RKO as a...

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Detalles Bibliográficos
Autores principales: Kobylarz, Marek J., Goodwin, Jonathan M., Kang, Zhao B., Annand, John W., Hevi, Sarah, O’Mahony, Ellen, McAllister, Gregory, Reece-Hoyes, John, Wang, Qiong, Alford, John, Russ, Carsten, Lindeman, Alicia, Beibel, Martin, Roma, Guglielmo, Carbone, Walter, Knehr, Judith, Loureiro, Joseph, Antczak, Christophe, Wiederschain, Dmitri, Murphy, Leon O., Menon, Suchithra, Nyfeler, Beat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446895/
https://www.ncbi.nlm.nih.gov/pubmed/32833964
http://dx.doi.org/10.1371/journal.pone.0235551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446895/
https://www.ncbi.nlm.nih.gov/pubmed/32833964
http://dx.doi.org/10.1371/journal.pone.0235551

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