Restricting extracellular Ca(2+) on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca(2+) response, which consequently enhances gefitinib sensitivity

Non-small cell lung cancer (NSCLC), one of the leading causes of cancer-related death, has a low 5-year survival rate owing to the inevitable acquired resistance toward antitumor drugs, platinum-based chemotherapy, and targeted therapy. Epidermal growth factor (EGF)-EGF receptor (EGFR) signaling act...

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Detalles Bibliográficos
Autores principales: Kim, Mi Seong, Kim, So Hui, Yang, Sei Hoon, Kim, Min Seuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447054/
https://www.ncbi.nlm.nih.gov/pubmed/32841278
http://dx.doi.org/10.1371/journal.pone.0238155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447054/
https://www.ncbi.nlm.nih.gov/pubmed/32841278
http://dx.doi.org/10.1371/journal.pone.0238155

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