The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions...

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Detalles Bibliográficos
Autores principales: Shi, Xiaoshan, Chang, Chunmei, Yokom, Adam L, Jensen, Liv E, Hurley, James H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447430/
https://www.ncbi.nlm.nih.gov/pubmed/32773036
http://dx.doi.org/10.7554/eLife.59099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447430/
https://www.ncbi.nlm.nih.gov/pubmed/32773036
http://dx.doi.org/10.7554/eLife.59099

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