Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each c...

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Detalles Bibliográficos
Autores principales: Yeo, Syn Kok, Zhu, Xiaoting, Okamoto, Takako, Hao, Mingang, Wang, Cailian, Lu, Peixin, Lu, Long Jason, Guan, Jun-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447441/
https://www.ncbi.nlm.nih.gov/pubmed/32840210
http://dx.doi.org/10.7554/eLife.58810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447441/
https://www.ncbi.nlm.nih.gov/pubmed/32840210
http://dx.doi.org/10.7554/eLife.58810

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