Cargando…

Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeo, Syn Kok, Zhu, Xiaoting, Okamoto, Takako, Hao, Mingang, Wang, Cailian, Lu, Peixin, Lu, Long Jason, Guan, Jun-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447441/ https://www.ncbi.nlm.nih.gov/pubmed/32840210 http://dx.doi.org/10.7554/eLife.58810

Ejemplares similares

FAK signaling in Cancer-Associated Fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication
por: Wu, Hsin-Jung, et al.
Publicado: (2020)

Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing
por: Bosisio, Francesca Maria, et al.
Publicado: (2020)

A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors
por: Crowley, Laura, et al.
Publicado: (2020)

Distinctive pattern of AHNAK methylation level in peripheral blood mononuclear cells and the association with HBV‐related liver diseases
por: Sun, Libo, et al.
Publicado: (2018)

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model
por: Chen, Song, et al.
Publicado: (2016)

Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors
por: Genovese, Sara, et al.
Publicado: (2019)

Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations
por: Wong, Nelson K Y, et al.
Publicado: (2012)

Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells
por: Manupati, Kanakaraju, et al.
Publicado: (2022)

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing
por: Baslan, Timour, et al.
Publicado: (2020)

Killing Effects of IFN R(−/−) Mouse NK Cells Activated by HN Protein of NDV on Mouse Hepatoma Cells and Possible Mechanism with Syk and NF‐κB
por: Liang, Shuang, et al.
Publicado: (2019)

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression
por: Nguyen, Kim Bich, et al.
Publicado: (2023)

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation
por: Sun, Jin, et al.
Publicado: (2016)

Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR‐T790M mutation in non‐small cell lung cancer cells
por: Katayama, Yuki, et al.
Publicado: (2022)

Development of a novel cell line‐derived xenograft model of primary herpesvirus 8‐unrelated effusion large B‐cell lymphoma and antitumor activity of birabresib in vitro and in vivo
por: Nishimori, Tomohiro, et al.
Publicado: (2021)

Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells
por: Chang, Ming‐Min, et al.
Publicado: (2019)

The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line
por: Wang, Hai‐tao, et al.
Publicado: (2016)

Molecular heterogeneity in human papillomavirus‐dependent and ‐independent vulvar carcinogenesis
por: Swarts, Dorian R. A., et al.
Publicado: (2018)

Intratumor heterogeneity: A new perspective on colorectal cancer research
por: Zheng, Zicheng, et al.
Publicado: (2020)

EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty
por: Le Naour, Augustin, et al.
Publicado: (2020)

Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila
por: Narbonne-Reveau, Karine, et al.
Publicado: (2016)

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma
por: Kato, Takuya, et al.
Publicado: (2023)

Distinct genomic profile in h. pylori‐associated gastric cancer
por: Zhang, Xiaochen, et al.
Publicado: (2021)

Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine‐non‐neuroendocrine neoplasm
por: Zhang, Panpan, et al.
Publicado: (2021)

Influence of gene expression on survival of clear cell renal cell carcinoma
por: Berglund, Anders, et al.
Publicado: (2020)

Revealing the subtyping of non‐small cell lung cancer based on genomic evolutionary patterns by multi‐region sequencing
por: Liao, Gaoming, et al.
Publicado: (2020)

USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells
por: Lu, Qin, et al.
Publicado: (2019)

Targeting stanniocalcin‐1‐expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer
por: Abe, Kotaro, et al.
Publicado: (2021)

Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma
por: Yu, Xiang, et al.
Publicado: (2017)

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
por: DeBlasi, Janine M., et al.
Publicado: (2023)

Heterogeneity of d-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer
por: Prudnikova, Tatiana Y, et al.
Publicado: (2013)

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation
por: Stefanius, Karoliina, et al.
Publicado: (2019)

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis
por: Ye, Zu‐Lu, et al.
Publicado: (2019)

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
por: Li, Qiao, et al.
Publicado: (2014)

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
por: Foijer, Floris, et al.
Publicado: (2017)

Metabolomics analysis reveals distinct profiles of nonmuscle‐invasive and muscle‐invasive bladder cancer
por: Sahu, Divya, et al.
Publicado: (2017)

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis
por: Kümper, Sandra, et al.
Publicado: (2016)

Downregulation of miRNA‐141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting
por: Li, Ping, et al.
Publicado: (2017)

MiR‐335‐5p restores cisplatin sensitivity in ovarian cancer cells through targeting BCL2L2
por: Liu, Ruonan, et al.
Publicado: (2018)

miR‐541 suppresses proliferation and invasion of squamous cell lung carcinoma cell lines via directly targeting high‐mobility group AT‐hook 2
por: Xu, Li, et al.
Publicado: (2018)

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer
por: McGuirk, Shawn, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_egq50igjig2e31spokfcmp902j