Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripheral neuropathies. Moreover, these channels are aberrantly expressed in different cancers, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonache, M.Ángeles, Martín-Escura, Cristina, de la Torre Martínez, Roberto, Medina, Alicia, González-Rodríguez, Sara, Francesch, Andrés, Cuevas, Carmen, Roa, Ana María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447632/
https://www.ncbi.nlm.nih.gov/pubmed/32843690
http://dx.doi.org/10.1038/s41598-020-70691-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447632/
https://www.ncbi.nlm.nih.gov/pubmed/32843690
http://dx.doi.org/10.1038/s41598-020-70691-x

Ejemplares similares