Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

The gene regulatory network (GRN) of human cells encodes mechanisms to ensure proper functioning. However, if this GRN is dysregulated, the cell may enter into a disease state such as cancer. Understanding the GRN as a system can therefore help identify novel mechanisms underlying disease, which can...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Daniel, Studham, Matthew, Tjärnberg, Andreas, Weishaupt, Holger, Swartling, Fredrik J., Nordling, Torbjörn E. M., Sonnhammer, Erik L. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447758/
https://www.ncbi.nlm.nih.gov/pubmed/32843692
http://dx.doi.org/10.1038/s41598-020-70941-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447758/
https://www.ncbi.nlm.nih.gov/pubmed/32843692
http://dx.doi.org/10.1038/s41598-020-70941-y

Ejemplares similares