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Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA(B) receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice
Down syndrome is a complex genetic disorder caused by the presence of three copies of the chromosome 21 in humans. The most common models, carrying extra-copies of overlapping fragments of mouse chromosome 16 that is syntenic to human chromosome 21, are Ts2Cje, Ts1Cje and Ts1Rhr mice. In electrophys...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447763/ https://www.ncbi.nlm.nih.gov/pubmed/32843708 http://dx.doi.org/10.1038/s41598-020-71085-9 |