Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA(B) receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice

Down syndrome is a complex genetic disorder caused by the presence of three copies of the chromosome 21 in humans. The most common models, carrying extra-copies of overlapping fragments of mouse chromosome 16 that is syntenic to human chromosome 21, are Ts2Cje, Ts1Cje and Ts1Rhr mice. In electrophys...

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Detalles Bibliográficos
Autores principales: Arima-Yoshida, Fumiko, Raveau, Matthieu, Shimohata, Atsushi, Amano, Kenji, Fukushima, Akihiro, Watanave, Masashi, Kobayashi, Shizuka, Hattori, Satoko, Usui, Masaya, Sago, Haruhiko, Mataga, Nobuko, Miyakawa, Tsuyoshi, Yamakawa, Kazuhiro, Manabe, Toshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447763/
https://www.ncbi.nlm.nih.gov/pubmed/32843708
http://dx.doi.org/10.1038/s41598-020-71085-9

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