Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

A specific ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of six Uncaria alkaloids in mouse blood with midazolam as the internal standard (IS). Only 20 μL blood was needed for sample preparation, and the prote...

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Detalles Bibliográficos
Autores principales: Chen, Lianguo, Ma, Jianshe, Wang, Xianqin, Zhang, Meiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://www.ncbi.nlm.nih.gov/pubmed/32879877
http://dx.doi.org/10.1155/2020/1030269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448256/
https://www.ncbi.nlm.nih.gov/pubmed/32879877
http://dx.doi.org/10.1155/2020/1030269

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