Pharmacokinetics, Pharmacodynamics, and Safety of Nivolumab in Patients With Sepsis-Induced Immunosuppression: A Multicenter, Open-Label Phase 1/2 Study

BACKGROUND: Sepsis often induces an immunosuppressive state, which is associated with high mortality rates. Immunostimulation may be beneficial for sepsis. We investigated the pharmacokinetics, pharmacodynamics, and safety of nivolumab, a human programmed death-1 immune checkpoint inhibitor approved...

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Detalles Bibliográficos
Autores principales: Watanabe, Eizo, Nishida, Osamu, Kakihana, Yasuyuki, Odani, Motoi, Okamura, Tatsuaki, Harada, Tomohiro, Oda, Shigeto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Clinical Science Aspects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448837/
https://www.ncbi.nlm.nih.gov/pubmed/31513050
http://dx.doi.org/10.1097/SHK.0000000000001443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448837/
https://www.ncbi.nlm.nih.gov/pubmed/31513050
http://dx.doi.org/10.1097/SHK.0000000000001443

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