ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens

ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. Unlike other nucleos(t)ides, the active clevudine-5′-triphosphate is a noncompetitive, non-chain-terminating inhibitor of hepatitis B virus (HBV) poly...

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Detalles Bibliográficos
Autores principales: Squires, Katherine E., Mayers, Douglas L., Bluemling, Gregory R., Kolykhalov, Alexander A., Guthrie, David B., Reddy, Prabhakar, Mitchell, Debbie G., Saindane, Manohar T., Sticher, Zachary M., Edpuganti, Vindhya, De La Rosa, Abel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449170/
https://www.ncbi.nlm.nih.gov/pubmed/32540975
http://dx.doi.org/10.1128/AAC.00836-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449170/
https://www.ncbi.nlm.nih.gov/pubmed/32540975
http://dx.doi.org/10.1128/AAC.00836-20

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