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DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands
How parental histones, the carriers of epigenetic modifications, are deposited onto replicating DNA remains poorly understood. Here, we describe the eSPAN method (enrichment and sequencing of protein-associated nascent DNA) in mouse embryonic stem (ES) cells and use it to detect histone deposition o...
Autores principales: | Li, Zhiming, Hua, Xu, Serra-Cardona, Albert, Xu, Xiaowei, Gan, Songlin, Zhou, Hui, Yang, Wen-Si, Chen, Chun-long, Xu, Rui-Ming, Zhang, Zhiguo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449674/ https://www.ncbi.nlm.nih.gov/pubmed/32923642 http://dx.doi.org/10.1126/sciadv.abb5820 |
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