Transient intracellular acidification regulates the core transcriptional heat shock response

Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought to depend on ongoing protein synthesis. Here,...

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Detalles Bibliográficos
Autores principales: Triandafillou, Catherine G, Katanski, Christopher D, Dinner, Aaron R, Drummond, D Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449696/
https://www.ncbi.nlm.nih.gov/pubmed/32762843
http://dx.doi.org/10.7554/eLife.54880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449696/
https://www.ncbi.nlm.nih.gov/pubmed/32762843
http://dx.doi.org/10.7554/eLife.54880

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