Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts

OBJECTIVES: SSc is an autoimmune disease characterized by inflammation, vascular injury and excessive fibrosis in multiple organs. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that regulates processes involved in SSc pathology, such as inflammation and fibrosi...

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Detalles Bibliográficos
Autores principales: Carvalheiro, Tiago, Malvar Fernández, Beatriz, Ottria, Andrea, Giovannone, Barbara, Marut, Wioleta, Reedquist, Kris A, Garcia, Samuel, Radstake, Timothy R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449812/
https://www.ncbi.nlm.nih.gov/pubmed/31840182
http://dx.doi.org/10.1093/rheumatology/kez583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449812/
https://www.ncbi.nlm.nih.gov/pubmed/31840182
http://dx.doi.org/10.1093/rheumatology/kez583

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