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CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates

Protein misfolding causes a wide spectrum of human disease, and therapies that target misfolding are transforming the clinical care of cystic fibrosis. Despite this success, however, very little is known about how disease-causing mutations affect the de novo folding landscape. Here we show that inhe...

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Detalles Bibliográficos
Autores principales: Shishido, Hideki, Yoon, Jae Seok, Yang, Zhongying, Skach, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450043/
https://www.ncbi.nlm.nih.gov/pubmed/32848127
http://dx.doi.org/10.1038/s41467-020-18101-8