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CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
Protein misfolding causes a wide spectrum of human disease, and therapies that target misfolding are transforming the clinical care of cystic fibrosis. Despite this success, however, very little is known about how disease-causing mutations affect the de novo folding landscape. Here we show that inhe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450043/ https://www.ncbi.nlm.nih.gov/pubmed/32848127 http://dx.doi.org/10.1038/s41467-020-18101-8 |