Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila

Mutations in CHMP2B, encoding a protein in the endosomal sorting complexes required for transport (ESCRT) machinery, causes frontotemporal dementia linked to chromosome 3 (FTD3). FTD, the second most common form of pre-senile dementia, can also be caused by genetic mutations in other genes, includin...

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Detalles Bibliográficos
Autores principales: Lu, Yubing, West, Ryan J. H., Pons, Marine, Sweeney, Sean T., Gao, Fen-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450086/
https://www.ncbi.nlm.nih.gov/pubmed/32848189
http://dx.doi.org/10.1038/s41598-020-71097-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450086/
https://www.ncbi.nlm.nih.gov/pubmed/32848189
http://dx.doi.org/10.1038/s41598-020-71097-5

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