A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

Toxin-antitoxin systems are widespread stress-responsive elements, many of whose functions remain largely unknown. Here, we characterize the four DUF1814-family nucleotidyltransferase-like toxins (MenT(1–4)) encoded by the human pathogen Mycobacterium tuberculosis. Toxin MenT(3) inhibited growth of...

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Detalles Bibliográficos
Autores principales: Cai, Yiming, Usher, Ben, Gutierrez, Claude, Tolcan, Anastasia, Mansour, Moise, Fineran, Peter C., Condon, Ciarán, Neyrolles, Olivier, Genevaux, Pierre, Blower, Tim R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450476/
https://www.ncbi.nlm.nih.gov/pubmed/32923609
http://dx.doi.org/10.1126/sciadv.abb6651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450476/
https://www.ncbi.nlm.nih.gov/pubmed/32923609
http://dx.doi.org/10.1126/sciadv.abb6651

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