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A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems
Toxin-antitoxin systems are widespread stress-responsive elements, many of whose functions remain largely unknown. Here, we characterize the four DUF1814-family nucleotidyltransferase-like toxins (MenT(1–4)) encoded by the human pathogen Mycobacterium tuberculosis. Toxin MenT(3) inhibited growth of...
Autores principales: | Cai, Yiming, Usher, Ben, Gutierrez, Claude, Tolcan, Anastasia, Mansour, Moise, Fineran, Peter C., Condon, Ciarán, Neyrolles, Olivier, Genevaux, Pierre, Blower, Tim R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450476/ https://www.ncbi.nlm.nih.gov/pubmed/32923609 http://dx.doi.org/10.1126/sciadv.abb6651 |
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