Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis

Vascular permeability and angiogenesis underpin neovascular age-related macular degeneration and diabetic retinopathy. While anti-VEGF therapies are widely used clinically, many patients do not respond optimally, or at all, and small-molecule therapies are lacking. Here, we identified a dibenzoxazep...

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Detalles Bibliográficos
Autores principales: Li, Yue, Alhendi, Ahmad M. N., Yeh, Mei-Chun, Elahy, Mina, Santiago, Fernando S., Deshpande, Nandan P., Wu, Ben, Chan, Enoch, Inam, Shafqat, Prado-Lourenco, Leonel, Marchand, Jessica, Joyce, Rohan D., Wilkinson-White, Lorna E., Raftery, Mark J., Zhu, Meidong, Adamson, Samuel J., Barnat, François, Viaud-Quentric, Karen, Sockler, Jim, Mackay, Joel P., Chang, Andrew, Mitchell, Paul, Marcuccio, Sebastian M., Khachigian, Levon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450479/
https://www.ncbi.nlm.nih.gov/pubmed/32923607
http://dx.doi.org/10.1126/sciadv.aaz7815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450479/
https://www.ncbi.nlm.nih.gov/pubmed/32923607
http://dx.doi.org/10.1126/sciadv.aaz7815

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